In a groundbreaking discovery, researchers have found that Alzheimer's disease is driven in part by a collapse in the brain's energy balance, and fixing it can reverse the disease in animal models. Even mice with advanced Alzheimer's regained brain function and memory, suggesting recovery may be possible in humans.
The study reveals that the brain's metabolic dysfunction plays a critical role in Alzheimer's progression. By addressing this energy imbalance, scientists were able to not only halt the disease's advancement but actually reverse its effects, restoring cognitive abilities in affected mice.
In related research, scientists at the University of Vermont have uncovered new details about how blood circulation in the brain is controlled and how vascular problems might be reversed. Their preclinical findings suggest that replacing a missing phospholipid in the bloodstream could help restore normal brain blood flow and ease dementia-related symptoms.
These findings offer new hope for the millions of people worldwide affected by Alzheimer's and other forms of dementia, potentially paving the way for novel therapeutic approaches that target the brain's energy systems rather than just the protein plaques traditionally associated with the disease.
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